Βιβλιογραφία

2.1.1 Ξηρό, σκασμένο και «άγριο» δέρμα

http://www.bepanthen.de/de/hautprobleme/schuppig-rissige-hautstellen/
http://www.bepanthen.de/de/hautprobleme/schuppig-rissige-hautstellen/#tab_1

2.1.2 Πλένουμε τα χέρια μας - Φροντίζουμε το δέρμα μας

https://www.who.int/infection-prevention/campaigns/clean-hands/advocacy-slides-2019_short.pdf?ua=1
https://www.who.int/gpsc/5may/tools/who_guidelines-handhygiene_summary.pdf
Lachapelle, J., Gimenez-Arnau, A., Metz, M., Peters, J. and Proksch, E., 2017. Best practices, new perspectives and the perfect emollient: optimizing the management of contact dermatitis. Journal of Dermatological Treatment, 29(3), pp.241-251
Behroozy A, Keegel TG. Wet-work exposure: a main risk factor for occupational hand dermatitis.Saf Health Work 2014;5:175–180
Loden M, Andersson AC. Effect of topically applied lipids on surfactant-irritated skin. Br J Dermatol1996; 134: 215–20.
Ramsing DW, Agner T. Preventive and therapeutic effects of amoisturizer. An experimental study of human skin.
Diepgen, T., Andersen, K., Chosidow, O., Coenraads, P., Elsner, P., English, J., Fartasch, M., Gimenez-Arnau, A., Nixon, R., Sasseville, D. and Agner, T., 2015. Guidelines for diagnosis, prevention and treatment of hand eczema. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 13(1), pp.e1-e22.

2.1.3. Μάθετε για τα ελαφρά εγκαύματα ή εγκαύματα πρώτου βαθμού

http://www.mayoclinic.org/first-aid/first-aid-burns/basics/art-20056649
Bayer Minor Wounds e-detailer
Bayer Minor Wounds e-detailer
http://www.mayoclinic.org/first-aid/first-aid-burns/basics/art-20056649
http://www.nhs.uk/Conditions/Burns-and-scalds/Pages/Treatment.aspx

2.1.4 Η δομή του δέρματός σου

http://www.bepanthengamme.fr/fr/creme/#tab_0 Proksch,
Ehrhardt, Johanna M. Brandner, and Jens‐Michael Jensen. "The skin: an indispensable barrier." Experimental dermatology 17.12 (2008): 1063-1072.
http://www.bepanthengamme.fr/fr/creme/#tab_0
https://www.nursingtimes.net/clinical-archive/dermatology/understanding-the-structure-and-function-of-the-skin/205222.fullarticle

2.1.5 Ήλιος, δέρμα και φωτοευαισθησία

Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermato-endocrinology. Jan 1 2013;5(1):51-108.
Diffey BL. Solar ultraviolet radiation effects on biological systems. Physics in medicine and biology. Mar 1991;36(3):299-328.
Ravanat JL, Douki T, Cadet J. Direct and indirect effects of UV radiation on DNA and its components. Journal of photochemistry and photobiology. B, Biology. Oct 2001;63(1-3):88-102.
Norval M, Halliday GM. The consequences of UV-induced immunosuppression for human health. Photochemistry and photobiology. Sep-Oct 2011;87(5):965-977.
Vermeer BJ, Hurks M. The clinical relevance of immunosuppression by UV irradiation. Journal of photochemistry and photobiology. B, Biology. Aug 1994;24(3):149-154.
European Medicines Agency. ICH Guidance S10 on Photosafety Evaluation of Pharmaceuticals. Paper presented at: Committee for Human Medicinal Products 2015.
Khandpur S, Porter RM, Boulton SJ, Anstey A. Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science. The British journal of dermatology. Apr 2017;176(4):902-909.
Lim HW, Arellano-Mendoza MI, Stengel F. Current challenges in photoprotection. Journal of the American Academy of Dermatology. Mar 2017;76(3s1):S91-s99.

2.2.2 Μάθετε για τα συγκάματα στα μωρά

Hoath, S.B. and Maibach, H.I. (2003) Neonatal skin: Structure and function.
http://www.bepantolbaby.com.br/pt/familiaebebe/cuidados-com-assaduras/
http://www.nhs.uk/Conditions/pregnancy-and-baby/Pages/Nappy-rash.aspx
http://www.bepantolbaby.com.br/pt/familiaebebe/cuidados-com-assaduras/
http://www.bepanthengamme.fr/fr/pommade/erytheme-fessier/
http://www.nhs.uk/Conditions/pregnancy-and-baby/Pages/Nappy-rash.aspx
Peters, M. British Medical Association Complete Home Medical Guide (4th Ed.). (2016)
http://www.nhs.uk/Conditions/pregnancy-and-baby/Pages/Nappy-rash.aspx
http://www.bepanthen.ie/en/bepanthensupsup-ointment/nappy-rash/

2.2.3 Συγκάματα στα μωρά

Paulman, P.M., Paulman, A., Harrison, J.D., Nasir, L.S., Bryan, S.K. and Collier, D.S. (2011) Signs and symptoms in family medicine: A literature-based approach.
http://www.bepanthen.ie/en/bepanthensupsup-ointment/care-tips/
http://www.nhs.uk/Conditions/pregnancy-and-baby/Pages/Nappy-rash.aspx#rashprevention
Schachner LA and Hansen RC (2011) Pediatric Dermatology
Putet, G. et al. Bepanthen ointment in the prevention of diaper rash onpremature andfullterm babies: open pilot study.Real Pediatr 2001;63: 33 – 38.
Biro et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis 2003; 49: 80-84
Bissett D.L. Common cosmeceuticals. Clin Dermatol 2009; 27:435 - 445
Camargo FB.. et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2001;62 (4):361-370.
Ebner F. et al. Topical Use of Dexpanthenol in Skin Disorders.. Am J Clin Dermatol 3, 2002;427-433
Gehring W., Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000; 50 (7):659-663.
Presto S. et al. Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001;76: 86-90
Proksch E., Nissen H-P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 13, 2002;173-178

2.3.1 Μπορεί το άγχος να προκαλέσει ατοπική δερματίτιδα;

Griesemer, Robert D. "Emotionally triggered disease in a dermatologic practice." Psychiatric Annals 8.8 (1978): 49-56.
Altemus, Margaret, et al. "Stress-induced changes in skin barrier function in healthy women." Journal of Investigative Dermatology 117.2 (2001): 309-317.
Garg, Amit, et al. "Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders." Archives of dermatology 137.1
Bockelbrink, A., et al. "Atopic eczema in children: another harmful sequel of divorce." Allergy 61.12 (2006): 1397-1402.

2.3.2 Ατοπική Δερματίτιδα ή Έκζεμα

http://www.bepanthen.de/de/hautprobleme/geroetete-juckende-hautstellen/#tab_2
http://www.nhs.uk/Conditions/Eczema-%28atopic%29/Pages/Treatment.aspx
http://www.mayoclinic.org/diseases-conditions/eczema/basics/treatment/con-20032073
https://www.bepanthengamme.fr/fr/sensicalm/
http://www.bepanthengamme.fr/fr/sensicalm/
https://www.bepanthengamme.fr/fr/sensicalm/#tab_2

2.3.3 Τήρηση ενός ημερολογίου για την υγεία του δέρματος

Williams, Hywel C. Atopic dermatitis: the epidemiology, causes and prevention of atopic eczema. Cambridge University Press, 2000. Σελίδα 25
Werfel, T., et al. "Eczematous reactions to food in atopic eczema:position paper of the EAACI and GA2LEN." Allergy 62.7 (2007): 723-728.
http://www.who.int/dietphysicalactivity/fruit/en/index2.html
Ehlers I, Worm M, Sterry W, Zuberbier T. Sugar is not an aggravating factor in atopic dermatitis. Acta Dermatol Venereol 2001, 81: 282-284.

2.3.4 Τι είναι η Ατοπική Δερματίτιδα

http://www.bepanthen.de/de/hautprobleme/geroetete-juckende-hautstellen/#tab_1
http://www.mayoclinic.org/diseases-conditions/eczema/basics/causes/con-20032073
http://www.bepanthengamme.fr/fr/sensicalm/#tab_2
http://www.mayoclinic.org/diseases-conditions/eczema/basics/symptoms/con-20032073
http://www.bepanthengamme.fr/fr/sensicalm/

2.3.5 Πώς να αντιμετωπίσω το έκζεμα στο πρόσωπό μου;

Hoeger, P. H., et al. "The treatment of facial atopic dermatitis in children who are intolerant of, or dependent on, topical corticosteroids: a randomized, controlled clinical trial." British Journal of Dermatology 160.2 (2009): 415-422
http://www.mayoclinic.org/diseases-conditions/eczema/basics/treatment/con-20032073
Ring, Johannes, et al. "Guidelines for treatment of atopic eczema (atopic dermatitis) part I." Journal of the European Academy of Dermatology and Venereology 26.8 (2012): 1045-1060.
http://www.nhs.uk/conditions/emollients/Pages/Introduction.aspx
http://www.eczemacanada.ca/en/For-Adults/Makeup-and-Cleansers
Ring, Johannes, et al. "Guidelines for treatment of atopic eczema (atopic dermatitis) part I." Journal of the European Academy of Dermatology and Venereology 26.8 (2012): 1045-1060.
https://nationaleczema.org/eczema/child-eczema/infants-toddlers/

2.3.6 Γιατί έχω φαγούρα στο πρόσωπό μου;

Willis, C. M., et al. "Sensitive skin: an epidemiological study." British Journal of Dermatology 145.2 (2001): 258-263.
Sicherer, Scott H., and Hugh A. Sampson. "9. Food allergy." Journal of Allergy and Clinical Immunology 117.2 (2006): S470-S475.
http://www.mayoclinic.org/diseases-conditions/hay-fever/basics/treatment/con-20020827
http://www.nhs.uk/conditions/Prickly-heat/Pages/Introduction.aspx
Mehta, Surjit Singh, and Belum Siva Nagi Reddy. "Cosmetic dermatitis–current perspectives." International journal of dermatology 42.7 (2003): 533-542.
http://www.mayoclinic.org/diseases-conditions/itchy-skin/basics/lifestyle-home-remedies/con-20028460
Hairong, DONG Yinmao WANG Changtao YU. "The Elementary Study of Cosmetic with Cucumber Juice [J]." Flavour Fragrance Cosmetics 3 (2007): 006.

2.5.1 Μάθετε για την Ξηροφθαλμία

Gayton JL. Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol. 2009; 3:405-4122.
Yao. W. Dry Eye Syndrome: An Update in Office Management. The American Journal of Medicine. 2011; 124:1016-1018
Golden M.I. Dry Eye Syndrome -StatPearls -NCBI Bookshelf. 2020:1-7

2.5.2 Ξηροφθαλμία

Gayton JL. Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol. 2009; 3:405-412
https://www.eyeeco.com/blog/2355-simple-lifestyle-changes-good-dry-eyes.htmlAccessed 02.12.2020
Golden M.I. Dry Eye Syndrome -StatPearls -NCBI Bookshelf. 2020:1-7
Yao. W. Dry Eye Syndrome: An Update in Office Management. The American Journal of Medicine. 2011; 124:1016-1018
AAO PPP Cornea/External Disease Committee, Hoskins Center for Quality Eye Care. Dry Eye Syndrome PPP -2018
https://nyulangone.org/conditions/dry-eye-syndrome/treatments/lifestyle-modifications-for-dry-eye-syndrome Accessed 02.12.2020

2.6.1 Τι είναι η ξηροδερμία;

Farage MA. The prevalence of sensitive skin. Front Med. 2019;6:98.
Roussaki-Schulze AV, Zafiriou E, Nikoulis D, Klimi E, Rallis E, Zintzaras E. Objective biophysical findings in patients with sensitive skin. Drugs Exp Clin Res. 2005;31 (Suppl.):17–24.
Proksch, E. et al, (2019). Dry skin management: practical approach in light of latest research on skin structure and function. Journal of Dermatological Treatment. DOI: 0.1080/09546634.2019.1607024
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients—recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774. doi:10.1111/j.1610-0387.2005.05068.x.
Chen Y, Lyga J. Brain-skin connection: Stress, inflammation and skin aging. Inflamm Allergy Drug Targets. 2014;13(3):177-190. doi:10.2174/1871528113666140522104422.
Blume Peytavi. Gerontologist, 2016, Vol. 56, No. S2, S230–S242doi:10.1093/geront/gnw003
Seite J Eur Acad Dermatol Venereol 2011 May; Importance of treatment of skin xerosis in diabetes. 25(5):607-9. doi: 10.1111/j.1468-3083.2010.03807.x.
Proksch_J Dtsch Dermatol Ges_2005. The management of dry skin with topical emollients - recent perspectives. JDDG; 2005:3:768±774
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-8411 Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 - 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients-- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773

2.6.2 Πώς να επιλέξετε το σωστό προϊόν για το ξηρό δέρμα;

Ehrhardt Proksch, Enzo Berardesca, Laurent Misery, Johan Engblom & Joke Bouwstra (2019): Dry skin management: practical approach in light of latest research on skin structure and function, Journal of Dermatological Treatment, DOI: 10.1080/09546634.2019.1607024
Chen Y, Lyga J. Brain-skin connection: Stress, inflammation and skin aging. Inflamm Allergy Drug Targets. 2014;13(3):177-190.
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-8411 Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 - 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients-- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773

2.6.3 Η «από μέσα προς τα έξω» προσέγγιση στην περιποίηση της επιδερμίδας

Proksch E, et al. (2019): Dry skin management: practical approach in light of latest research on skin structure and function, Journal of Dermatological Treatment, DOI:10.1080/09546634.2019.1607024
Wohlrab J, Kreft D. Niacinamide - mechanisms of action and its topical use in dermatology. Skin Pharmacol Physiol. 2014;27(6):311-315. doi:10.1159/000359974.
Proksch E. The role of emollients in the management of diseases with chronic dry skin. Skin Pharmacol Physiol. 2008;21(2):75-80. doi:10.1159/000112957

3.1.1.1 Bepanthol^® Baby Balm

Peltier, E.; Mekideche, K.; Branka, J.E.; Trapp, S. New Insights in the Skin Protective Activity of a Dexpanthenol Containing Formula (Bepanthen) in a Diaper Rash-Like Model. J. Cosmet. Dermatol. Sci. Appl. 2020, 10, 76–8
Proksch, E., de Bony, R., Trapp, S., Boudon, S. Topical use of dexpanthenol: a 70th anniversary article. Journal of Dermatological Treatment. 2017 28(8), 766-773
Putet, G. et al. Bepanthen ointment in the prevention of diaper rash on premature and full-term babies: open pilot study.Real Pediatr 2001;63: 33 – 38Peltier, E.; Mekideche, K.; Branka, J.E.; Trapp, S. New Insights in the Skin Protective Activity of a Dexpanthenol Containing Formula (Bepanthen) in a Diaper Rash-Like Model. J. Cosmet. Dermatol. Sci. Appl. 2020, 10, 76–84.
Peltier, E.; El-Shazly, MA.; Blenkiron, P.; Crowther, JM. P1136 Two In-vitro studies comparing the friction lowering and protective properties of diaper care products; EADV: Vienna, Austria, 2020 [Abstract; e-poster]
Αξιολόγηση από φροντιστές μωρών και μητέρες σχετικά με την ευκολία εφαρμογής και αφαίρεσης του προϊόντος. Test report, Bayer Consumer Health, March 2020.
Dubecq J.P., Detchart M. Study on a dexpanthenol containing ointment in prevention and treatment of cracked nipples. Med Praticienne 1977; 665: 154-155.
Atherton, D., Proksch, E., Schauber, J., & Stalder, J. F. (2015). Irritant diaper dermatitis supplement part 1: best practice management. -Selfcare 6(S1):1-11

3.2.1.1 Bepanthene^® Eczema

Οδηγίες χρήσης Bepanthene^® Eczema, Bayer 2015. Διαβάστε το Φύλλο Οδηγιών Χρήσης
Stettler H. Improved itch relief with new product formulation for topical treatment in patients with mild-to-moderate atopic dermatitis: results from an exploratory trial. Key Opinions in Medicine.2016;11(4):1-7.
Darsow U, Wollenberg A, Simon D et al. ETFAD/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis. J Eur Acad Dermatol Venereol. 2010;24:317–328.
Cork M, Danby S. Skin barrier breakdown: a renaissance in emollient therapy. British Journal of Nursing. 2009;Vol 18, No 14
Ellis C et al. Br J Dermatol. International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies. 2003;148(Suppl 63):3–10.
Rawlings AV. Trends in stratum corneum research and the management of dry skin conditions. Int J Cosmet Sci. 2003; 25(1-2):63-95.
Proksch E, Bradner MJ, Jensen JM. The skin: an indispensable barrier. Experimental Dermatology. 2008;17:1063-1072
Abiko Y, Tomikaw M, Shimizu M. Enzymatic conversion of pantothenylalcohol to pantothenic acid. J Vitaminology.1969;15: 59-69.
Gehring W, Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Arzneimittelforschung. 2000 Jul;50(7):659-63.
Ebner F, Heller A, Rippke F, Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol. 2002; 3(6): 427-433.
Proksch E, Nissen HP. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment. 2002;13:173-178.
Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology. 2008;159(1):23-34.
Yosipovitch G, Papoiu ADP. What causes itch in atopic dermatitis? Curr Allergy Asthma Rep. 2008;8:306–311.

3.2.2 Bepanthene SensiDaily^®

Stettler H et al. A new topical panthenol containing emollient for maintenance treatment of childhood atopic dermatitis: results from a multicenter prospective study. J Dermatolog Treat 2017;28:774–779
Polańska A et al. Nonlesional skin in atopic dermatitis is seemingly healthy skin – observations using noninvasive methods. Videosurg Miniinv Techniques 2013;3:192–199.
Tollefson MM et al. Atopic dermatitis: Skin-directed management. Pediatrics 2014;134:e1735–1744.
Van Smeden J et al. The important role of stratum corneum lipids for cutaneous barrier function. Biochim Biophys Acta 2014;1841:295–313.
Proksch E et al. Role of the epidermal barrier in atopic dermatitis. J German Soc Dermatol2009;7:899–910.
Stettler H et al. A new topical panthenol containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora. J Dermatolog Treat 2017;28:173–180.
Branco CT and Guimarães JP. Modulation of skin microbiota by topical prebiotics. H&PC Today –Skin Care Supplement 2015;10:21–27.
Προϊοντική σύνθεση Bepanthene Sensidaily^®
Daniels R (2003): Richtige Basispflege ist wichtig. Pham. Ztg. 46: 26ff
Shai A et al. (2009): Handbook of Cosmetic Skin Care 2nd edition:28
Stettler H et al. (2017b): A new topical panthenol-containing emollient: Skin moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants. J Dermatolog Treat. 2017 May;28(3):251-257.

3.3.1.1 Bepanthol® Derma Επανόρθωση Κρέμα Προσώπου με SPF25 50 ml

Πρόγραμμα Κλινικών Μελετών Επανόρθωση Κρέμα Προσώπου με SPF25 50 ml
1. In-Home Use Test – Evaluation of the Efficacy of One Facial Cosmetic Product on Hydration and Skin Lipids (Corneometry, Questionnaire)
2. Non-Comedogenicity Test under Dermatological Control
3. Human Patch Test under Dermatological Control
4. Human Repeated Insult Patch Test with Challenge
5. SLS-Challenge Test – Evaluation of the Efficacy of two Cosmetic Products on Skin Barrier Recovery
6. Phototoxicity Test – Assessment of the Phototoxic Potential of two Cosmetic Formulations after Single Application in Adult Subjects under Dermatological Control
7. Photosensitivity Test – Evaluation of Photosensitization Potential of tow Cosmetic Formulations Applied to Healthy Human Subjects
8. Determination of the Sun Protection Factor (SPF) in vivo of Three Cosmetic Face Day Creams with SPF
9. Determination of the UVA Protection Factor (UVAPF) in vivo of the Three Cosmetic Face Day Creams with SPF
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 – 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol.2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient.International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients -- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110

3.3.1.2 Bepanthol® Derma Ενισχυμένη Επανόρθωση Ενυδατική Κρέμα Προσώπου Ημέρας 50 ml

Πρόγραμμα Κλινικών Μελετών Ενισχυμένη Επανόρθωση Ενυδατική Κρέμα Προσώπου Ημέρας
1. In-Home Use Test – Evaluation of the Efficacy of One Facial Cosmetic Product on Hydration and Skin Lipids (Corneometry, Questionnaire)
2. Non-Comedogenicity Test under Dermatological Control
3. Human Patch Test under Dermatological Control
4. Human Repeated Insult Patch Test with Challenge
5. SLS-Challenge Test – Evaluation of the Efficacy of two Cosmetic Products on Skin Barrier Recovery
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 – 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol.2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Orth DS, Appa Y: Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, editors. Dry Skin and Moisturizers. Boca Raton, Florida: CRCPress; 2000 p. 213-28
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient.International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients -- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110

3.3.1.3 Bepanthol® Derma Ενισχυμένη Επανόρθωση Κρέμα Προσώπου Νυκτός 50 ml

Πρόγραμμα Κλινικών Μελετών Ενισχυμένμη Επανόρθωση Κρέμα Προσώπου Νυκτός
1. In-Home Use Test – Evaluation of the Efficacy of One Facial Cosmetic Product on Hydration and Skin Lipids (Corneometry, Questionnaire)
2. Non-Comedogenicity Test under Dermatological Control
3. Human Patch Test under Dermatological Control
4. Human Repeated Insult Patch Test with Challenge
5. SLS-Challenge Test – Evaluation of the Efficacy of two Cosmetic Products on Skin Barrier Recovery
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 – 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol.2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Orth DS, Appa Y: Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, editors. Dry Skin and Moisturizers. Boca Raton, Florida: CRCPress; 2000 p. 213-28
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient.International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients -- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110

3.3.2.1 Bepanthol® Derma Απαλός Καθαρισμός Προσώπου Kαθημερινό Gel 200 ml

Πρόγραμμα Κλινικών Μελετών Απαλός Καθαρισμός Προσώπου Kαθημερινό Gel
1. Human Patch Test under Dermatological Control
2. Human Repeated Insult Patch Test with Challenge
3. In-Home Use Test – Human In Use Test under Dermatological Control and Instrumental Evaluation (Corneometry, Questionnaire, TEWL)
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 – 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol.2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Orth DS, Appa Y: Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, editors. Dry Skin and Moisturizers. Boca Raton, Florida: CRCPress; 2000 p. 213-28
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient.International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients -- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110

3.3.3.1 Bepanthol® Derma Επανόρθωση Καθημερινό Γαλάκτωμα Σώματος με Αντλία 400 ml

Πρόγραμμα Κλινικών Μελετών Επανόρθωση Καθημερινό Γαλάκτωμα Σώματος
1. Human Patch Test under Dermatological Control
2. Human Repeated Insult Patch Test with Challenge
3. In-Home Use Test (2 tests) – Human In Use Test under Dermatological Control and Instrumental Evaluation (Corneometry, Questionnaire)
4. SLS-Challenge Test – Evaluation of the Efficacy of Two Cosmetic Products on Skin Barrier Recovery
5. SLS-Challenge Test – Evaluation of the Efficacy of a Cosmetic Product on Skin Barrier Recovery
6. Phototoxicity Test – Assessment of the Phototoxic Potential of two Cosmetic Formulations after Single Application in Adult Subjects under Dermatological Control
7. Photosensitivity Test – Evaluation of Photosensitization Potential of tow Cosmetic Formulations Applied to Healthy Human Subjects
8. In-home use test with a new body lotion to assess the safety and tolerability in children with a history of atopic dermatitis under pediatrician’s control, including a toxicological analysis.
9. Diabetic Dry Skin – In-home use test with a cosmetic body lotion to assess the performance and tolerability after topical application in diabetic adult subjects under dermatological control
10. Science Visualization – Exploratory In-home Performance Test to Examine how a Cosmetic Body Balm Designed to Improve Skin Hydration Affects Epidermal Differentiation after Topical Application in Adult Subjects with Dry Skin under Dermatological Control
11. In-Home Use Test – In-home use test with a new body lotion to assess the safety and tolerability in children with a history of atopic dermatitis under pediatrician’s control
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 - 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3(2):88-93
Guéhenneux S et al, Skin Surface Hydration Decreases Rapidly During Long Distance Flights. Skin Res Technol. 2012; 18 (2): 238-40
Hon KL, Wong KY, Leung TF, Chow CM, Ng PC. Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, Nottingham Eczema Severity Score, and quality of life in patients with atopic dermatitis. Am J Clin Dermatol. 2008;9(1):45-50
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Morton C et al, Pruritus and skin hydration during dialysis. Nephrol Dialysis Transplantation. 1996; 11 (10): 2031-2036.
Orth DS, Appa Y: Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, editors. Dry Skin and Moisturizers. Boca Raton, Florida: CRC Press; 2000 p. 213-28
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients-- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110
Stettler et al. P0597: Performance, acceptability and tolerability of a new dexpanthenol-containing emollient in the care of dry skin in adult diabetics. Virtual EADV 2020
Stettler, H.; de Salvo, R.; Olsavszky, R.; Nanu, E.A.; Dumitru, V.; Trapp, S. Performance and Tolerability of a New Topical Dexpanthenol-Containing Emollient Line in Subjects with Dry Skin: Results from Three Randomized Studies. Cosmetics 2021, 8, 18. https://doi.org/10.3390/ cosmetics8010018

3.3.3.2 Bepanthol® Derma Ενισχυμένη Επανόρθωση Καθημερινό Γαλάκτωμα Σώματος με Αντλία 400 ml

Πρόγραμμα Κλινικών Μελετών Ενισχυμένη Επανόρθωση Καθημερινό Γαλάκτωμα Σώματος
1. Human Patch Test under Dermatological Control
2. Human Repeated Insult Patch Test with Challenge
3. In-Home Use Test – Human In Use Test under Dermatological Control and Instrumental Evaluation (Corneometry, Questionnaire)
4. SLS-Challenge Test – Evaluation of the Efficacy of Two Cosmetic Products on Skin Barrier Recovery
5. SLS-Challenge Test – Evaluation of the Efficacy of a Cosmetic Product on Skin Barrier Recovery
6. Diabetic Dry Skin – In-home use test with a cosmetic body lotion to assess the performance and tolerability after topical application in diabetic adult subjects under dermatological control
7. Science Visualization – Exploratory In-home Performance Test to Examine how a Cosmetic Body Balm Designed to Improve Skin Hydration Affects Epidermal Differentiation after Topical
8. Application in Adult Subjects with Dry Skin under Dermatological Control
9. In-Home Use Test – In-home use test with a new body lotion to assess the safety and tolerability in children with a history of atopic dermatitis under pediatrician’s control
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 - 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3(2):88-93
Guéhenneux S et al, Skin Surface Hydration Decreases Rapidly During Long Distance Flights. Skin Res Technol. 2012; 18 (2): 238-40
Hon KL, Wong KY, Leung TF, Chow CM, Ng PC. Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, Nottingham Eczema Severity Score, and quality of life in patients with atopic dermatitis. Am J Clin Dermatol. 2008;9(1):45-50
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Morton C et al, Pruritus and skin hydration during dialysis. Nephrol Dialysis Transplantation. 1996; 11 (10): 2031-2036.
Orth DS, Appa Y: Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, editors. Dry Skin and Moisturizers. Boca Raton, Florida: CRC Press; 2000 p. 213-28
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients-- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110
Stettler, H.; de Salvo, R.; Olsavszky, R.; Nanu, E.A.; Dumitru, V.; Trapp, S. Performance and Tolerability of a New Topical Dexpanthenol-Containing Emollient Line in Subjects with Dry Skin: Results from Three Randomized Studies. Cosmetics 2021, 8, 18. https://doi.org/10.3390/ cosmetics8010018

3.3.4.1 Bepanthol® Derma Απαλός Καθαρισμός Σώματος Καθημερινό Αφρόλουτρο Gel 400 ml

Πρόγραμμα Κλινικών Μελετών Απαλός Καθαρισμός Σώματος Καθημερινό Αφρόλουτρο
1. Human Patch Test under Dermatological Control
2. Human Repeated Insult Patch Test with Challenge
3. In-Home Use Test – Human In Use Test under Dermatological Control and Instrumental Evaluation (Corneometry, Questionnaire, TEWL)
4. In-Home Use Test- In-home use test with a new body wash to assess the safety and tolerability in healthy children under pediatrician’s control
5. In-vitro testing Epiocular -Topical application ocular irritation screening assay using the epiocular™ human cell construct
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 - 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3(2):88-93
Guéhenneux S et al, Skin Surface Hydration Decreases Rapidly During Long Distance Flights. Skin Res Technol. 2012; 18 (2): 238-40
Hon KL, Wong KY, Leung TF, Chow CM, Ng PC. Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, Nottingham Eczema Severity Score, and quality of life in patients with atopic dermatitis. Am J Clin Dermatol. 2008;9(1):45-50
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Morton C et al, Pruritus and skin hydration during dialysis. Nephrol Dialysis Transplantation. 1996; 11 (10): 2031-2036.
Orth DS, Appa Y: Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, editors. Dry Skin and Moisturizers. Boca Raton, Florida: CRC Press; 2000 p. 213-28
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients-- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773

3.3.5 Bepanthol Derma Επανόρθωση Κρέμα Χεριών

In-Home Use Test– In-Use Test: Dermatological Use Study with a Hand Cream on Very Dry and Sensitive Skin (Corneometry, TEWL, Questionnaire)
SLS-Challenge Test – Evaluation of the efficacy of a cosmetic product on Skin Barrier Recovery and Protection (48h Corneometry)
SLS-Challenge Test – Evaluation of the Efficacy of Two Cosmetic Products on Skin Barrier Recovery
Phototoxicity Test – Assessment of the Phototoxic Potential of one Cosmetic Formulation after Single Application in Adult Subjects under Dermatological Control
Photosensitivity Test – Evaluation of Photosensitization Potential of one Cosmetic Formulation Applied to Healthy Human Subjects
Use Test: Dermatological Tolerability Evaluation on Subjects with History of Hand Eczema
Use Test: Dermatological Tolerability Evaluation on Diabetics
Σύνθεση προϊόντος
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a doubleblind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 - 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27:469-474
Orth DS, Appa Y: Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, editors. Dry Skin and Moisturizers. Boca Raton, Florida: CRC Press; 2000 p. 213-28
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients-- recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110

3.4.1 Bepanthol^® Ενυδατική Κρέμα Προσώπου

Gehring W, Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Drug Research 2000;50 (ΙΙ): 659 – 663
Camargo F.B. et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 62, 2011; (4):361-370.
Biro et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis. 2003; 49, 80-84
Bissett DL. Common cosmeceuticals. Clin Dermatol 2009; 27, 435 - 445
Ebner et al. Topical Use of Dexpanthenol in Skin Disorders.. Am J Clin iDermatol 3, 2002;427-433
Presto et al. Stimulation of epidermal regeneration by 5% dexpanthenol – results of a placebo-controlled double-blind study. Z f Hautkr 76,2001; 86-90
Proksch & Nissen. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 13, 2002; 173-178
Burke KE. Photodamage of the skin: protection and reversal with topical antioxidants. J Cosmet Dermatol 2004; 3: 149-155.
Dreher F, Maibach HI (2001) Protective effects of topical antioxidants in humans. In: Thiele J, Elsner P (eds.) Oxidants and antioxidants in cutaneous biology. Curr Probl Dermatol, 29:157-164
Nachbar F, Korting HC (1995), The role of vitamin E in normal and damaged skin, J Mol Med, 73: 7-17
Lupo M, Antioxidants and Vitamins in Cosmetics. Clinics in Dermatology, 2001;19:467-473
Sharma Bh. and Sharma Ar. Future prospect of nanotechnology in development of anti-ageing formulations. International Journal of Pharmacy and Pharmaceutical Sciences, 2012, Vol 4, Issue 3 57-66

3.4.2 Bepanthol^® Intensive Κρέμα Προσώπου-Ματιών

Κλινικές μελέτες προϊόντος
Biro K et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis. 2003; 49, 80-84.
Bissett DL. Common cosmeceuticals. Clin Dermatol 2009;27, 435 – 445.
Camargo FB et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci 2011;62 (4):361-370.
Ebner F et al. Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002;3:427-433.
Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology. 2008;159(1):23-34.
Gehring W, Fluhr J, Gloor M. Influence of vitamin E acetate on stratum corneum hydration, Arzneimittelforschung 48, 1998; (7), 772-775
Gehring W., Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung 2000;50 (7):659-663.
Presto S et al. Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001;76, 86-90.
Proksch E., Nissen H.P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002;13, 173-178.

3.4.3 Bepanthol^® Αντιρυτιδική Κρέμα για Πρόσωπο-Μάτια-Λαιμό

Κλινική αξιολόγηση 40 γυναικών μετά από 28 ημέρες
Εσωτερική θρέψη επιδερμίδας λόγω μειωμένης διαδερμικής απώλειας νερού.
Προσωπικές αξιολογήσεις, 40 γυναίκες, χρήση 4 εβδομάδες, 2 φορές/ημέρα.

3.5.1 Bepanthol^® Γαλάκτωμα Σώματος

Gehring W, Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Drug Research 2000;50 (ΙΙ): 659 - 663
Ebner F. et al. Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002;3:427-433.
Del Rosso J., Levin J.SKIN STRUCTURE AND FUNCTION, The Clinical Relevance of Maintaining the Functional Integrity of the Stratum Corneum in both Healthy and Disease-affected Skin, The Journal of Clinical and Aesthetic Dermatology, Sept. 2011; Vol.4, Num. 9
Rawlings A.V. et al. Skin Moisturisation. Dry and Xerotic Skin Conditions. Marcel Dekker Inc., New York, 2002;6:119-120
Κλινικές μελέτες προϊόντος

3.5.2 Bepanthol^® Κρέμα Χεριών

Biro K et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis. 2003; 49, 80-84
Bissett DL. Common cosmeceuticals. Clin Dermatol 2009;27, 435 – 445
Camargo FB et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci 2011;62 (4):361-370
Ebner F et al. Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002;3:427-433
Gehring W., Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung 2000;50 (7):659-663
Presto S et al. Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001;76, 86-90
Proksch E., Nissen H.P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002;13, 173-178
Κλινικές δοκιμές προϊόντος

3.5.3 Bepanthol^® Αφρόλουτρο

Bouwstra J, Gooris G, Ponec M. Skin lipid organisation, Composition and Barrier function. IFSCC magazine 2007:10, 297 - 307
Bissett DL. Common cosmeceuticals. Clin Dermatol 2009;27, 435 - 445
Camargo FB et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci 2011;62 (4):361-370
Ebner F et al. Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002;3:427-433
Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology 2008;159(1):23-34
Gehring W, Gloor M.Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung 2000;50 (7):659-663
Orth DS, Appa Y. Glycerine: A Natural Ingredient for Moisturizing Skin. In: Loden M, Maibach HI, (ed). Dry Skin and Moisturizers. Boca Raton, Florida, CRC Press, 2000 (p. 213-28)

3.5.4 Bepanthol^® Κρέμα

Biro K. et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis. 2003; 49: 80-84.
Bissett DL. Common cosmeceuticals. Clin Dermatol. 2009;27: 435 – 445.
Camargo FB et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011;62 (4):361-370.
Ebner F. et al. Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol. 2002;3:427-433.
Gehring W, Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Drug Research. 2000;50 (ΙΙ): 659 – 663.
Presto S. et al. Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr. 2001;76, 86-90.
Proksch E, Nissen H.P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment. 2002;13, 173-178.
Cosmetic Test Report IMPACT 19685 (performance), F. Addor,
Comparative study to assess the performance of three cosmetic products on dry skin through instrumental and subjective clinical assessment.
Leyden JL, Lavker R. Photodamage and Dry Skin. J Toxicol – Cut & Ocular Toxicol. 2002; 21(3): 255-263.
Proksch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70th anniversary article. Journal of Dermatological Treatment. 2017; 28(8): 766-773
Cosmetic Test Report IMPACT 20577 (tolerability and performance), F. Addor, Evaluation of the safety and efficacy of the product Bepantol® Cream (UI 1600188) after the dermatological procedure in the face – 21 days of follow-up. 12. Addor, F.A.S.; de Souza, M.C.; Trapp, S.; Peltier, E.; Canosa, J.M. Efficacy and Safety of Topical Dexpanthenol-Containing Spray and Cream in the Recovery of the Skin Integrity Compared with Petroleum Jelly after Dermatologic Aesthetic Procedures. Cosmetics 2021, 8, 87. https://doi.org/10.3390/ cosmetics8030087.
Canosa JM et al. P1128 Comparative evaluation of the performance of two cosmetic products on dry skin clinically, instrumentally and subjectively. Abstract e-poster Virtual EADV 2021.
Goujon C. et al (2001) F. Study of the efficacy and tolerance of Bepanthen cream on irritant hand dermatitis Réalités Térapeutiques en Dermato-Venerologie 2001; 2-11.
Cosmetic Test Report (RO 01-4709/362) (performance), A. Frappaz,
Study of the efficacy and safety of Bepanthen® cream on irritative dermatitis on hands.

3.5.5 Bepanthol^® Balm

Biro et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis 2003; 49: 80-84
Bissett D.L. Common cosmeceuticals. Clin Dermatol 2009; 27:435 - 445
Camargo FB. et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2001;62 (4):361-370.
Ebner F. et al. Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 3, 2002;427-433
Gehring W., Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000; 50 (7):659-663.
Presto S. et al. Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001;76: 86-90
Proksch E., Nissen H-P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 13, 2002;173-178
Goujon-Henry C. et al. Randomized single-blind pilot comparison study of the efficacy and tolerability of Bepanthen Ointment in subjects with bilateral dryness of the hands. Réalités Thérapeutiques en Dermato-Vénérologie. 1997;107: 81-90
Olsavszky R. et al. Skin barrier restoration upon topical use of two 5% dexpanthenol water-in-oil formulations on freshly tattooed skin: results from a single-blind prospective study. Wounds International 2019; Vol 10, Issue 1:33-39
Dubecq J.P., Detchart M. Study on a dexpanthenol containing ointment in prevention and treatment of cracked nipples. Med Praticienne 1977; 665: 154-155.
Putet, G. et al. Bepanthen ointment in the prevention of diaper rash on premature and fullterm babies: open pilot study. Real Pediatr 2001;63: 33 – 38.

3.5.6 Bepanthol^® Σπρέι Αφρού

Karajiannis H. et al. BEPANTHEN BURN RELIEF FOAM SPRAY: Scientific Rationale, Switzerland, 2001

3.5.7 Bepanthol^® Gentle Tattoo Wash

Κλινική μελέτη και ερωτηματολόγιο, Bayer
Σύνθεση Bepanthol Gentle Tattoo Wash
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Diagnosis and treatment of xerosis cutis - a position paper. J Dtsch Dermatol Ges. 2019 Nov;17 Suppl 7:3-33
Barrionuevo-Gonzalez, A.; Trapp, S.; de Salvo, R.; Olsavszky, R.; Nanu, E.A.; Dopcea, I.; Dumitru, V.; Stettler, H. Two New Dexpanthenol-Containing Wash Gels: Skin Hydration, Barrier Function and Cosmetic Performance upon Single and Repeated Usage in Subjects with Dry Skin. Cosmetics 2021, 8, 44
Biro K et al: Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis 2003 49, 80-84
Bissett DL: Common cosmeceuticals. Clin Dermatol 2009 27, 435 - 445
Camargo FB et al: Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 62 (4):361-370
Cork M & Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs. 2009 18 (14): 872-7
Ebner F et al: Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002 3, 427-433
Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 159(1):23-34
Gehring W & Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000 50 (7):659-663
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3(2):88-93
Lawton S: Skin barrier function and the use of emollients in dermatological nursing. Br J Nurs. 2007 16(12):712-9
Manela-Azulay M et al.: Cosmeceutical vitamins. Clinics in Dermatology 2009 27: 469-474
Otte N et al.: Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 2005 72: 255-261
Presto S et al: Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001 76, 86-90
Proksch E & Nissen: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002 13, 173-178
Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773
Proksch E, Lachapelle J-M. The management of dry skin with topical emollients--recent perspectives. J Dtsch Dermatol Ges. 2005;3(10):768-774
Proksch E: The Role of Emollients in the Management of Diseases with Chronic Dry Skin. Skin Pharmacol Physiol. 2008 21:75-80
Κλινική μελέτη in vivo, Bayer

3.6.1 Bepanthene® Eye Drops

Οδηγίες Χρήσης Bepanthene® Eye Drops
Σύνθεση Bepanthene®EyeDrops
Causes of Dry Eye. National Eye Institute. Accessed 04.08.2020. https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/dry-eye/causes-dry-eye
Gayton JL. Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol. 2009; 3:405-412
Milicic N. et al. Corneal epithelialization after photorefractive keratectomy using sodium hyaluronate/dexpanthenol preservative free eye drops, ESCRS Barcelona 2015

3.7.1 Bepanthol^® Tattoo Balm

Κλινική μελέτη δέρμα με νέο tattoo, Bayer 2018.
Αποτελέσματα ερωτηματολογίου που συμπληρώθηκε από 56 άτομα με νέο tattoo σε επισκέψεις τους τη 2η, 7η και 14η ημέρα μετά το τατουάζ. Η Bepanthol^® Tattoo Balm εφαρμόστηκε στο νέο τατουάζ 4-8 φορές/ημέρα για 14 ημέρες. Κλινική μελέτη δέρμα με νέο tattoo, Bayer 2018.
Biro K. et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis. 2003;49, 80 – 84
Bissett DL. Common cosmeceuticals. Clin Dermatol. 2009;27, 435 – 445
Camargo FB et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2001;62 (4), 361 – 370
Ebner F et al. Topical use of dexpanthenol in skin sisorders. Am J Clin Dermatol. 2002; 3, 427 – 433
Gehring W & Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung. 2000;50 (7), 659 – 663
Goujon N. et al. Randomized single-blind pilot comparison study of the efficacy and tolerability of Bepanthen Ointment in subjects with bilateral dryness of the hands. Réalités Thérapeutiques en Dermato-Vénérologie. 1997;107, 81 – 90
Presto S. et al. Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr. 2001;76, 86 – 90
Proksch E. & Nissen H-P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. J Dermatol Treatment. 2002;13, 173 – 178
Proksch E., de Bony R., Trapp S., & Boudon S. Topical use of dexpanthenol: a 70th anniversary article. Journal of Dermatological Treatment. 2017;28(8), 766-773
Olsavszky R. et al. Skin barrier restoration upon topical use of two 5% Dexpanthenol water-in-oil formulations on freshly tattooed skin: results from a single-blind prospective study. Wounds International 2019(10);1:33-9
In vitro test, Bayer 2010
Σύνθεση προϊόντος

3.7.2 Bepanthol Tattoo Αντηλιακή Κρέμα SPF50+

Κλινική μελέτη και ερωτηματολόγιο, Bayer
Σύνθεση Bepanthol Tattoo Αντηλιακή Κρέμα SPF 50+
Biro K, Thaçi D, Ochsendorf FR, Kaufmann R, Boehncke WH. (2003): Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis. 49(2): 80-84
Bissett DL (2009): Common cosmeceuticals. Clin Dermatol 27, 435 - 445
Camargo FB Jr1, Gaspar LR, Maia Campos PM. (2011): Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 62(4):361-370
Ebner F, Heller A, Rippke F, Tausch I. (2002): Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol.3(6):427-433
Gehring W, Gloor M (2000): Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung 50(7):659-663.
Gonzalez C et.al (2019): Ultraviolet radiation may cause premature fading of colored tattoos. Photodermatol Photoimmunol Photomed. 36:73–74
Presto et al (2001): Stimulation of epidermal regeneration by 5% dexpanthenol – results of a placebo-controlled double-blind study. Z f Hautkr 76, 86-90
McVean M, Liebler DC. (1999): Prevention of DNA photodamage by vitamin E compounds and sunscreens: roles of ultraviolet absorbance and cellular uptake. Mol Carcinog. 24(3):169-176
Norkus EP, Bryce GF, Bhagavan HN. (1993): Uptake and bioconversion of alpha-tocopheryl acetate to alpha-tocopherol in skin of hairless mice. Photochem Photobiol. 57(4):613-15
Thiele JJ, Hsieh SN, Ekanayake-Mudiyanselage S. (2005): Vitamin E: critical review of its current use in cosmetic and clinical dermatology. Dermatol Surg. ;31(7 Pt 2):805-813
Thiele JJ, Schroeter C, Hsieh SN, Podda M, Packer L.(2001):The antioxidant network of the stratum corneum. Curr Probl Dermatol. 29:26-42.
Wu CM, Cheng YL, Dai YH, Chen MF, Wang CC. (2014): α-Tocopherol protects keratinocytes against ultraviolet A irradiation by suppressing glutathione depletion, lipid peroxidation and reactive oxygen species generation. Biomed Rep. 2(3):419-423
Kλινική μελέτη in vivo, Bayer
Κλινική μελέτη in vitro, Bayer
Data on efficacy of 0,25% tocopherol :
Erixon, Anna (Sept 2014): Merck support document on Coppertone anti-oxidant claim

4.0 Σχετικά με τη Bepanthol^®

Biro K. et al. Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study Contact Dermatitis. 2003; 49, 80-84.
Bissett DL. Common cosmeceuticals. Clin Dermatol 2009;27, 435 – 445.
Camargo FB et al. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci 2011;62 (4):361-370.
Ebner F. et al. Topical Use of Dexpanthenol in Skin Disorders. Am J Clin Dermatol 2002;3:427-433.
Gehring W, Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Drug Research 2000;50 (ΙΙ): 659 – 663
Presto S. et al. Stimulation of epidermal regeneration by 5% dexpanthenol - results of a placebo-controlled double-blind study. Z f Hautkr 2001;76, 86-90.
Proksch E, Nissen H.P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate- induced irritation. J Dermatol Treatment 2002;13, 173-178.
Goujon Ν. et al. Randomized single-blind pilot comparison study of the efficacy and tolerability of Bepanthen Ointment in subjects with bilateral dryness of the hands. Réalités Thérapeutiques en Dermato-Vénérologie. 1997;107: 81-90
https://www.bepanthen.com.au/en/about-bepanthen/

5.1 Εκτεταμένη χρήση μάσκας; Βοηθήστε το δέρμα σας να «αναπνέει»

Damiani G, et al. COVID-19 related masks increase severity of both acne (maskne) and rosacea (mask rosacea): Multi-center, real-life, telemedical, and observational prospective study. Dermatologic Therapy, 2021;e14848
Szepietowski JC, et al. Face mask-induced itch: A self-questionnaire study of 2315 responders during the COVID-19 pandemic. Acta Derm Venereol, 2020;100:adv00152
Moshirfar M, et al. Face Mask-Associated Ocular Irritation and Dryness. Ophthalmol Ther. 2020 Sep; 9(3): 397–400.
Centre for Ocular Research & Education (CORE) and University of Waterloo. Mask associated dry eye. Available from: www.COVIDEyeFacts.org)
https://www.usdermatologypartners.com/blog/maskne-is-the-new-acne/
Yan Y, et al. Consensus of Chinese experts on protection of skin and mucous membrane barrier for health-care workers fighting against coronavirus disease 2019. Dermatol Ther, 2020;e13310.
Lupo M, Antioxidants and Vitamins in Cosmetics. Clinics in Dermatology, 2001;19:467-473
Οδηγίες χρήσης Bepanthene^® Eczema, Bayer 2015.
Stettler H. Improved itch relief with new product formulation for topical treatment in patients with mild-to-moderate atopic dermatitis: results from an exploratory trial. Key Opinions in Medicine, 2016;11(4):1-7.
Οδηγίες Χρήσης Bepanthene Eye Drops, Bayer 2020.

5.3 Σύστημα Διαχείρισης Ατοπικού Δέρματος

Thomsen SF. Atopic dermatitis: Natural history, diagnosis and treatment. ISRN Allergy 2014;2014:354250
Προϊοντική σύνθεση Bepanthene^® Eczema.
Stettler H et al. Improved itch relief with new product formulation for topical treatment in patients with mild-to-moderate atopic dermatitis: results from an exploratory trial. KOM Dermatol 2016;11:1–10.
Προϊοντική σύνθεση Bepanthene Sensidaily^®.
Stettler H et al. A new topical panthenol containing emollient for maintenance treatment of childhood atopic dermatitis: results from a multicentre prospective study. J Dermatolog Treat 2017;28:774–779.
Stettler H et al. A new topical panthenol containing emollient: Skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants. J Dermatolog Treat 2017;28:251–257.

5.4 Tattoo aftercare tips by Bepanthol

Κλινικές προϊόντικές μελέτες και ερωτηματολόγια, Bayer
Σύνθεση Bepanthol Tattoo Balm
Σύνθεση Bepanthol Tattoo Αντηλιακή Κρέμα SPF 50+
Σύνθεση Bepanthol Gentle Tattoo Wash
Barrionuevo-Gonzalez, A.; Trapp, S.; de Salvo, R.; Olsavszky, R.; Nanu, E.A.; Dopcea, I.; Dumitru, V.; Stettler, H. Two New Dexpanthenol-Containing Wash Gels: Skin Hydration, Barrier Function and Cosmetic Performance upon Single and Repeated Usage in Subjects with Dry Skin. Cosmetics 2021, 8, 44
Biro et al. (2003): Effect of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis 49, 80 – 84
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